The New Antibacterial Hydrogel Coating to Protect Prosthesis and Biomaterials

Implanted biomaterials may get colonized by bacteria during surgery...

 

Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.

 

Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.

VIDEO of biofilm formation

 

An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.

Antibacterial coatings classification

 

DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants. 

 

  
 

Risultati immagini per dac hydrogel

 

 

 

Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)

 

 


 

VIDEOS

(may take few minutes to upload)

 

Mechanism of Implant-Related Infection

  DAC Barrier Effect

Surgical Technique

  
  


 

Visit also 

www.dac-coating.com [English]

www.oudshoornbv.com [Dutch]

 


 

 Scientific Publications:

 

Frontiers in Medicine 2020 

The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel

 

 Hip International 2020

Antibiotic-loaded Hydrogel Coated Revision Hip Prosthesis 

 

Journal of Bone and Joint Infection 2020

Antimicrobial Coated Orthopaedic Implants Efficacy: a Systematic Review and Meta-Analysis

 

 ClinicalTrials 2020

Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery 

 

Microorganisms 2020:

Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery

 

ECM 2020

Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits

 

Muscles, Ligaments and Tendons Journal 2020:

Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study

 

Bone & Joint Research 2019:

Antibacterial coating of implants: are we missing something? 

 

Eur Rev 2019:

Orthopaedic oncology and antibacterial coatings

 

Maitrise Orthopedique Journal 2019:

Surgical Technique and Clinical Applications (see full text below)

 

JOA 2018:

Cost-benefit balance of DAC and other antibacterial coatings 

 

Dr. Willemijn Boot - PhD thesis 2018: 

Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands

 

 Int Orthop 2018:

Two-stage hip revision with DAC coating provides better results than without

 

 Hydrogels 2018:

Hydrogel coating: from basic research to clinical applications

 

KSSTA 2018:

Clinical application to one-stage revision of PJI

 

Orthop Proceedings 2018:

Clinical application to two-stage hip revision of PJI

 

Antibacterial Coating of Implants in Ortho-Trauma - Springer Ed. 2018

 

 JORT 2017 :

 Clinical application to osteosynthesis and fracture fixation devices 

  

JBJI 2017:

 Anti-adhesive and anti-bacterial effects of hyaluronic acid

  

CORR 2017:

No interference of antibiotic-looaded hydrogel with bone healing in the animal model

 

 BJJ 2017-2 

 

BJJ 2017-1

 

 

 

Chapter 9. Infection after Joint Arthroplasy - Thieme Ed. 2017

 by A. Chen, CL Romanò, L Drago, J Parvizi

  

JBJI 2016:

Clinical application to joint prosthesis

 

 BJJ 2016-1

 

BJJ 2016-2

 

Med Inflamm 2016

 

 Copertina anteriore 

Paradigm change in antibacterial coatings - Springer Ed. 2016

 

JOSR 2015:

Antibacterial Coating of Implants in Orthopaedics and Trauma: A Classification Proposal

 

 Orthop Today 2015

 

CORR 2015

 

BJJ 2015

The Management of Periprosthetic Infections in the Future

 

eCM 2015

 

BJJ 2014 

 

CORR 2014 

 

Int Orthop 2014

  

Copertina anteriore

Biomaterials for Medicine - Universitas Studiorum Ed. 2014

 

MSIS 2013 

 

Int J Pharm 2013

  

 BJJ 2011 

   

The New Antibacterial Hydrogel Coating to Protect Prosthesis and Biomaterials - DAC Implant Coating Protection

DAC is the result of a international project, funded by the European Community under the 7th Framework Programme, aimed at developing a resorbable, biocompatible antibacterial coating, able to prevent infection of implanted biomaterials in orthopaedcs.

To learn more, visit the official website of  iDAC Project 

 

 

A Barrier Against Infection

 

 

Risultati immagini per dac hydrogel

 

Clinical Indications:

DAC is a CE marked medical device, specifically designed to protect implanted biomaterials from bacterial adhesion and colonization, in order to reduce or prevent the occurrence of post-surgical infections.

The device can be used to protect cementless and hybrid (partially cemented) joint prosthesis (hip, knee, shoulder, etc.), fracture fixation devices (plates, nails, screws, etc.), dental implants, etc..

All patients may take advantage from the antibacterial protection offered by DAC hydrogel, that is especially useful for those patients at higher risk for infection (e.g.: old-aged patients, diabetic and/or obese, smokers, alcohol or drug abusers, immunocompromised hosts, malnurished or oncological patients, etc.) and/or undergoing high risk procedures (revision or tumor surgery, contaminated procedures, etc.).

   

For more information on DAC technology:

www.dac-coating.com