Implanted biomaterials may get colonized by bacteria during surgery...
Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.
Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.
An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.
Antibacterial coatings classification
DAC (Defensive Antibacterial Coating) is
the first fully resorbable coating specifically designed
to prevent bacterial colonization of joint prosthesis and osteosynthesis implants.
Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)
More VIDEOS
Mechanism of Implant-Related Infection
Scientific Background
Antibacterial hydrogel coating in complex high-risk primary and cementless hip revision arthroplasty
Eur J Orthop Surg Traumatol 2025
Distal Femur Replacement for Infected Bone Defects Due to End-Stage Periprosthetic Joint Infection or Trauma
The Efficacy of Defensive Antibacterial Coating (DAC™) Periprosthetic Joint Infection Prevention in the Hip.
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Local Bacteriophage Therapy for Fracture-Related Infection with Polymicrobial Multi-Resistant Bacteria
Single-Stage Transcutaneous Osseointegrated Prosthesis for Above-Knee Amputations Including an Antibiotic-Loaded Hydrogel
Recent Advancements in Hydrogel Biomedical Research in Italy
Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections
What to Know about Antimicrobial Coatings in Arthroplasty: A Narrative Review
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Hydrogel Coating versus Calcium Sulphate Beads in Acute Periprosthetic Joint Infection
Advances in Hygiene and Experimental Medicine 2023
Defensive Antibacterial Coating (DAC) Hydrogel for the Therapy of Achilles Tendon Infection
Incidence and Cost of Post-Operative Wound Infections in Patients Treated or Untreated with DAC® Antibacterial Hydrogel
Defensive Antibacterial Coating (DAC®) in Orthopaedic Surgery: A Narrative Review
Antibacterial Coatings on Orthopedic Implants
Local Antibiotic Delivery Options in Prosthetic Joint Infection
A Fabricated Hydrogel of Hyaluronic Acid/Curcumin to Heal the Bacterial Infected Wound
Antibiotic-Loaded Coatings to Reduce Fracture-Related Infections
Frontiers in Bioengineering and Biotechnology 2023
Potential Side Effects of Antibacterial Coatings in Orthopaedic Implants
Polysaccharide-Based Coatings as Drug Delivery Systems
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High Rate of Infection Eradication Following Cementless One-Stage Revision Hip Arthroplasty with an Antibacterial Hydrogel Coating.
Implant Surface Modifications as a Prevention Method for Periprosthetic Joint Infection: a Systematic Review and Meta-analysis
Research, Society and Development 2022
Utilização do Hidrogel (DAC) na Prevenção de Infecções em Procedimentos com Fixação Interna Estável (FIE)
Antibacterial Coating of Implants: What Surgeons Should Know
High Molecular Weight Hyaluronic Acid Reduces the Expression of Virulence Genes
Rapidly Aging Society and the Need for Multifunctional Bioactive Coatings for Orthopedic Applications
Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance
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DAC® Antibacterial Hydrogel Coating for Megaprosthesis
Clinical Application of Antibacterial Hydrogel and Coating in Orthopaedic and Traumatology Surgery
Antibiotic-Loaded Hydrogel Coating for the Prevention of Local Infection after Vertebral Surgery
Single-stage Revision of MRSA Orthopedic Device-related Infection in Sheep with an Antibiotic-loaded Hydrogel
Functional Hydrogel Coating
Reconstruction of infected post-traumatic bone defects of the distal femur
Brazilian Journal of Oral and Maxillofacial Surgery 2021
Hidrogel Sobre Material de Fixação em Cirurgias Maxilofaciais
Advances in Oral and Maxillofacial Surgery 2021
Protective Hydrogel to Heal Post-maxillofacial Surgery Paresthesia?
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DAC® Hydrogel in Maxillo-Facial Surgery: a Case Report
The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel
Hip International 2020
Antibiotic-loaded Hydrogel Coated Revision Hip Prosthesis
Paper of the Week
Journal of Bone and Joint Infection 2020
Antimicrobial Coated Orthopaedic Implants Efficacy:
a Systematic Review and Meta-Analysis
Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery
Stability Evaluation and Degradation Studies of DAC® Hyaluronic-Polylactide Based Hydrogel by DOSY NMR Spectroscopy
Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery
Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits
Muscles, Ligaments and Tendons Journal 2020
Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study
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Traumatology and Orthopedics of Russia 2019
Local Antibacterial Implant Protection in Orthopedics and Trauma: What’s New ?
Antibacterial coating of implants: are we missing something?
Orthopaedic oncology and antibacterial coatings
Maitrise Orthopedique Journal 2019
Surgical Technique and Clinical Applications (see full text below)
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Cost-benefit balance of DAC and other antibacterial coatings
Dr. Willemijn Boot - PhD thesis 2018
Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands
Two-stage hip revision with DAC coating provides better results than without
Hydrogel coating: from basic research to clinical applications
Clinical application to one-stage revision of PJI
Clinical application to two-stage hip revision of PJI
Antibacterial Coating of Implants in Ortho-Trauma - Springer Ed. 2018
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Clinical application to osteosynthesis and fracture fixation devices
Anti-adhesive and anti-bacterial effects of hyaluronic acid
No interference of antibiotic-looaded hydrogel with bone healing in the animal model
Chapter 9. Infection after Joint Arthroplasy - Thieme Ed. 2017
by A. Chen, CL Romanò, L Drago, J Parvizi
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Clinical application to joint prosthesis
