Implanted biomaterials may get colonized by bacteria during surgery...
Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.
Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.
An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.
Antibacterial coatings classification
DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants.
Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)
VIDEOS
Mechanism of Implant-Related Infection
Scientific Background
DAC® Antibacterial Hydrogel Coating for Megaprosthesis
The Potential Innovative Use of Bacteriophages Within the DAC® Hydrogel
Hip International 2020
Antibiotic-loaded Hydrogel Coated Revision Hip Prosthesis
Journal of Bone and Joint Infection 2020
Antimicrobial Coated Orthopaedic Implants Efficacy: a Systematic Review and Meta-Analysis
Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery
Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery
Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits
Muscles, Ligaments and Tendons Journal 2020
Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study
Antibacterial coating of implants: are we missing something?
Orthopaedic oncology and antibacterial coatings
Maitrise Orthopedique Journal 2019
Surgical Technique and Clinical Applications (see full text below)
Cost-benefit balance of DAC and other antibacterial coatings
Dr. Willemijn Boot - PhD thesis 2018
Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands
Two-stage hip revision with DAC coating provides better results than without
Hydrogel coating: from basic research to clinical applications
Clinical application to one-stage revision of PJI
Clinical application to two-stage hip revision of PJI
Antibacterial Coating of Implants in Ortho-Trauma - Springer Ed. 2018
Clinical application to osteosynthesis and fracture fixation devices
Anti-adhesive and anti-bacterial effects of hyaluronic acid
No interference of antibiotic-looaded hydrogel with bone healing in the animal model
Chapter 9. Infection after Joint Arthroplasy - Thieme Ed. 2017
by A. Chen, CL Romanò, L Drago, J Parvizi
Clinical application to joint prosthesis
Paradigm change in antibacterial coatings - Springer Ed. 2016
Antibacterial Coating of Implants in Orthopaedics and Trauma: A Classification Proposal
The Management of Periprosthetic Infections in the Future
Biomaterials for Medicine - Universitas Studiorum Ed. 2014
Surgical Tips on Maitrise Orthopedique 2019:
