Implanted biomaterials may get colonized by bacteria during surgery...
Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.
Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.
Look at a VIDEO of biofilm formation
An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.
Antibacterial coatings classification
DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants.
Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)
VIDEOS
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Mechanism of Implant-Related Infection
Presentations on VUMEDI
(for professionals only)
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Scientific publications:
Peri-prosthetic Joint Infection (PJI) has a tremendous social and economic impact in Europe and worldwide.
DAC is highly cost-effective when used to prevent septic complications in joint replacement.
JOA 2018 : Cost-benefit balance of DAC and other antibacterial coatings
Chapter 9: Antibacterial Coating of Implants in Orthopaedics and Trauma
Int Orthop 2018: Two-stage hip revision with DAC coating provides better results than without
Hydrogels IntechOpen 2018: Hydrogel coating: from basic research to clinical applications
KSSTA 2018: Clinical application to one-stage revision of PJI
Orthop Proceedings 2018: Clinical application to two-stage hip revision of PJI
JORT 2017 : Clinical application to osteosynthesis and fracture fixation devices
JBJI 2017 : Anti-adhesive and anti-bacterial effects of hyaluronic acid
CORR 2017 : No interference with bone healing in the animal model
JBJI 2016 : Clinical application to joint prosthesis
Paradigm change in antibacterial coatings - Springer Ed. 2016
eCM 2015 (University Medical Center Utrecht, Utrecht, The Netherlands)
BJJ 2015 (see below for full text)
BJJ 2014 - CORR 2014 - Int Orthop 2014
MSIS 2013 - Int J Pharm 2013 - BJJ 2011
Chapter 9. Infection after Joint Arthroplasy
by A. Chen, CL Romanò, L Drago, J Parvizi
