Implanted biomaterials may get colonized by bacteria during surgery...
Even if the surgical instruments and drapes are sterile at the beginning of surgery, bacteria may still reach the surgical wound and implants from patient's skin, from air and microparticles eventually present in the surgical room.
Once bacteria adhere to an implant, they start immediately producing biofilms, that make them much more resistant to host's immune defence system and to antibiotic activity.
Look at a VIDEO of biofilm formation
An antibacterial coating would be a simple and effective solution to prevent bacteria colonization of the implanted biomaterials and, finaly, to reduce post-surgical infections.
Antibacterial coatings classification
DAC (Defensive Antibacterial Coating) is the first fully resorbable coating specifically designed to prevent bacterial colonization of joint prosthesis and osteosynthesis implants.
Rationale for Intra-operative Mixing of DAC Hydrogel with Antibiotic(s)
VIDEOS
(may take few minutes to upload)
Mechanism of Implant-Related Infection
Visit also
www.dac-coating.com [English]
[Dutch]
Scientific publications:
ClinicalTrials 2020: Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery for Secondary Prevention of Complex Chronic Periprosthetic Hip Joint Infection
Microorganisms 2020: Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery
ECM 2020: Prophylaxis of Implant-Related Infections by Local Release of Vancomycin From a Hydrogel in Rabbits
Muscles, Ligaments and Tendons Journal 2020: Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study
Bone & Joint Research 2019: Antibacterial coating of implants: are we missing something?
Eur Rev 2019: Orthopaedic oncology and antibacterial coatings
JOA 2018 : Cost-benefit balance of DAC and other antibacterial coatings
Dr. Willemijn Boot PhD thesis, 2018 - Utrecht University, University Medical Center Utrecht, Utrecht, The Netherlands
Int Orthop 2018: Two-stage hip revision with DAC coating provides better results than without
Hydrogels 2018: Hydrogel coating: from basic research to clinical applications
KSSTA 2018: Clinical application to one-stage revision of PJI
Orthop Proceedings 2018: Clinical application to two-stage hip revision of PJI
JORT 2017 : Clinical application to osteosynthesis and fracture fixation devices
JBJI 2017 : Anti-adhesive and anti-bacterial effects of hyaluronic acid
CORR 2017 : No interference with bone healing in the animal model
Antibacterial Coating of Implants in Orthopaedics and Trauma 2017
JBJI 2016 : Clinical application to joint prosthesis
Paradigm change in antibacterial coatings - Springer Ed. 2016
JOSR 2015: Antibacterial Coating of Implants in Orthopaedics and Trauma: A Classification Proposal in an Evolving Panorama
eCM 2015 (University Medical Center Utrecht, Utrecht, The Netherlands)
BJJ 2015 (see below for full text)
Chapter 9. Infection after Joint Arthroplasy
by A. Chen, CL Romanò, L Drago, J Parvizi
